Can i take 600 mg of wellbutrin

His QTc peaked at but, he remained in sinus rhythm. Neurology was consulted for new onset seizure activity. Head CT was performed and read as normal. EEG indicated lowered seizure threshold with propensity for focal seizures in the right temporal region and was suggestive of severe encephalopathy. After 2 days in the ICU, the patient was extubated to nasal cannula and transferred to floor level of care. He was discharged on the 3 rd day of his hospital stay with instructions to follow up with his primary care physician and psychiatrist in one week.

Bupropion exerts its antidepressant actions via inhibition of dopamine and norepinephrine reuptake, and has antagonistic activity at the nicotinic acetylcholine receptor.

In contrast to many other antidepressants, bupropion has minimal serotonergic activity. Therapeutic doses of bupropion mg daily are generally well tolerated with the most common side effects being dry mouth and insomnia. At higher doses, bupropion causes a wide range of toxic effects similar to the effects produced by its related drugs of abuse. In mild to moderate toxic doses it produces agitation, hallucination, tachycardia, tremor, and single episodes of seizure.

In severe toxic doses it can cause coma, hypotension, multiple seizures, QRS widening, QTc prolongation, status epilepticus, and ventricular dysrhythmias [2]. Seizure due to intentional or unintentional overdose is among the most commonly reported toxic effect of bupropion [3—6]. In the vast majority of cases, bupropion induced seizure is preceded by a prodrome with agitation, tremor, or hallucination occurring prior to seizure [7].

The incidence of seizure is dose dependent, with seizure occurring with higher frequency at higher doses [8,9]. Bupropion is a significant cause of drug induced seizure. Of the total number of reported cases of bupropion induced seizure in this study, The inhibitory activity of bupropion on dopamine reuptake would seem to suggest addictive potential similar to that of cocaine or amphetamines. However, early studies of bupropion provided evidence to the contrary.

In comparison to dextroamphetamine, doses of bupropion ranging from mg did not produce the same behavioral or peripheral sympathomimetic effects seen with mg of dextroamphetamine [11,12]. The lack of sympathomimetic effects in these studies was likely dose related, as bupropion is generally well tolerated with standard therapeutic dosing.

Reports of recreational bupropion use surfaced in , nearly two decades after its original FDA approval for the treatment of depression [13,14]. The second case involved a year-old boy with a history of marijuana and alcohol use, that crushed and insufflated six mg bupropion tablets resulting in generalized tonic-clonic seizure.

Apart from seizures, the following may also occur:. Seizures are considered one of the most severe Wellbutrin SR side effects when the drug is taken in high doses. While seizures may occur, it is essential to understand that other potential signs and symptoms may indicate a Wellbutrin XL overdose or that a person has taken too much of another bupropion drug form. When a person notices signs related to Wellbutrin overdose, the first thing that needs to be done is to call It is vital that detailed information is provided to ensure understands where services like a paramedic may be required to assist the patient.

Once all details have been provided, it is always a good idea for a person to remain on the phone with the medical staff. These individuals are trained to provide patients in need of medical services with the guidance and ensure they understand what to expect and provide any details that should be given to the paramedics once they arrive.

While awaiting paramedics to arrive, it is advised that a person tries to remain as calm as possible. Following a pickup by the paramedics, a person will be taken to an emergency department for prompt treatment. The first step is for a physician to assess the person. A detailed report on the person will be required. The physician might ask the person if they took Wellbutrin XL mg or another dose or formulation of bupropion, as well as how many pills they took.

Once an assessment has been conducted, detoxification would be required. The most common detoxification procedure would be an oral administration of activated charcoal. Wellbutrin might be an effective drug for treating depression, or smoking cessation, but too much of bupropion can be life-threatening. Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety anxious depression : a pooled analysis of 10 studies.

J Clin Psychiatry, ;69 8 A pilot controlled trial of bupropion XL versus escitalopram in generalized anxiety disorder.

Psychopharmacol Bull, ; Effect of treatment with bupropion on EEG sleep: relationship to antidepressant response. Int J Neuropsychopharmacol. Antidepressants and their effect on sleep. Hum Psychopharmacol. Restless legs syndrome as side effect of second generation antidepressants. J Psychiatr Res. Bupropion and restless legs syndrome: a randomized controlled trial.

J Am Board Fam Med. Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depression: a meta-analysis. Other prominent adverse effects were agitation 39 patients [8.

Clinical outcomes were no effect patients [ Overall, patients